diff --git a/e2e/run/BUILD.bazel b/e2e/run/BUILD.bazel
index 139415376b4d5b997a10f5b17464f03a38baf3ea..34cf2f097f7878b1f8a28daec43d3a75e8c079ba 100644
--- a/e2e/run/BUILD.bazel
+++ b/e2e/run/BUILD.bazel
@@ -1,6 +1,7 @@
 load("@bazel_skylib//rules:write_file.bzl", "write_file")
 load("@rules_diff//diff/file/test:defs.bzl", "diff_file_test")
 load("@rules_labgrid//labgrid/genrule:defs.bzl", "labgrid_genrule")
+load("@rules_labgrid//labgrid/run/binary:defs.bzl", "labgrid_run_binary")
 load("@rules_python//python:defs.bzl", "py_binary")
 
 labgrid_genrule(
@@ -105,6 +106,24 @@ labgrid_genrule(
     tools = ["@rules_labgrid//labgrid/run"],
 )
 
+# Regression test for: https://gitlab.arm.com/bazel/rules_labgrid/-/issues/73
+labgrid_run_binary(
+    name = "hello-with-program-prefix",
+    srcs = ["@ape//ape:bash"],
+    outs = ["program-prefix.actual"],
+    args = [
+        "--program-prefix",
+        "''",
+        "--get",
+        "output.txt:$(location :program-prefix.actual)",
+        "$(location @ape//ape:bash)",
+        "-c",
+        "echo world > output.txt",
+    ],
+    platform = "@rules_labgrid//labgrid/platform:localhost",
+    tool = "@rules_labgrid//labgrid/run",
+)
+
 write_file(
     name = "expected",
     out = ":hello.txt",
@@ -131,5 +150,6 @@ write_file(
         "put-file-with-remote",
         "put-file-without-remote",
         "env",
+        "program-prefix",
     )
 ]
diff --git a/labgrid/run/__main__.py b/labgrid/run/__main__.py
index ae8eab7bf5bcd5f44d2b7630fcfbc01076c81710..b9021c529d61048e205c10bdddfaca93d8db1530 100644
--- a/labgrid/run/__main__.py
+++ b/labgrid/run/__main__.py
@@ -26,8 +26,8 @@ def arguments(prsr: ArgumentParser) -> None:
     )
     prsr.add_argument(
         "--program-prefix",
-        type=PurePath,
-        default=PurePath(""),
+        type=unquoted,
+        default="",
         help="Prefix of the path to the program on the device.",
     )
     prsr.add_argument(
@@ -70,6 +70,11 @@ def resolve(value: str) -> Path:
         return Path(value)
 
 
+def unquoted(value: str) -> str:
+    # FIXME: Extract `BazelArgumentParser` to handle quoting
+    return value.removeprefix("'").removesuffix("'")
+
+
 def env(arg: str) -> tuple[str, str]:
     key, sep, value = arg.partition("=")
     if not sep:
@@ -80,8 +85,7 @@ def env(arg: str) -> tuple[str, str]:
 
 
 def get(value: str) -> FileTransfer:
-    # FIXME: Extract `BazelArgumentParser` to handle quoting
-    remote, found, local = value.removeprefix("'").removesuffix("'").partition(":")
+    remote, found, local = unquoted(value).partition(":")
     optional = remote.endswith("?")
     if optional:
         remote = remote.removesuffix("?")
@@ -93,8 +97,7 @@ def get(value: str) -> FileTransfer:
 
 
 def put(value: str) -> FileTransfer:
-    # FIXME: Extract `BazelArgumentParser` to handle quoting
-    local, found, remote = value.removeprefix("'").removesuffix("'").partition(":")
+    local, found, remote = unquoted(value).partition(":")
     if found:
         local = Template(local).substitute(environ)
     else:
@@ -114,7 +117,7 @@ def main(exe: Path, *args: str) -> int:
         return run(
             parsed.program,
             *parsed.arguments,
-            program_prefix=parsed.program_prefix,
+            program_prefix=PurePath(parsed.program_prefix),
             downloads=parsed.downloads,
             uploads=parsed.uploads,
             env=dict(parsed.env),